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Targeting the AMPK activation through nutraceuticals. Resveratrol activates AMPK leading to apoptosis of colon cancer cells, enhance of cancer cell response to ionizing radiation, and mTOR-dependent and independent autophagy. Resveratrol also activates SIRT1, which improves AMPK activation, leading in turn to downregulation of mTOR. mTOR: mammalian target of rapamycin, SIRT1: Sirtuin-1. Grey and blue arrows indicate activation, T-bars indicate downregulation.
