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Basic mechanism of spliceosome assembly. ESS, exonic splicing silencer; ESE, exonic splicing enhancer; U1, U1 small nuclear ribonucleoprotein; SF1, splicing factor 1; U2AF, U2 auxiliary factor; SRp, SR (Ser-Arg) proteins; U2, small nuclear ribonucleoprotein; ATP, adenosine triphosphate; U4/U5/U6, U4/U5/U6 small nuclear ribonucleoprotein complex.
