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. 2017 Jan 29;18(2):294. doi: 10.3390/ijms18020294

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Heat-map generated for urine samples obtained from negative controls (C), patients with non-functioning adrenal incidentalomas (AI), and patients with Cushing’s syndrome (CS). Cluster A groups variables (steroid hormones) which do not generate differences in urinary steroid profiles of all studied individuals, cluster B includes steroid hormones which introduce the highest variability concerning urinary steroid profiles of control (C), and patient groups (AI and CS). Cluster I groups samples obtained from patients with Cushing’s syndrome (CS), cluster II includes samples from negative controls (C), and patients with non-functioning adrenal incidentalomas (AI).