Table 2.
Comparison of concentrations (mg/24 h urine) of nineteen steroid hormones analyzed in samples from negative controls, patients with non-functioning adrenal incidentalomas, and patients with Cushing’s syndrome, values given as medians and interquartile ranges and the results of ANOVA Kruskal–Wallis test, followed by Dunn’s test (statistical significance level at p < 0.05).
| Compound | Negative Control (n = 37) | Adrenal Incidentaloma (N = 25) | Cushing’s Syndrome (n = 16) | ANOVA Kruskal-Wallis Test Followed by Dunn’s Test |
|---|---|---|---|---|
| Androsterone | 0.79 | 0.78 | 0.85 | H = 15.21 |
| (0.76–0.83) | (0.7–0.81) | (0.83–0.91) | p < 0.001 | |
| Etiocholanolone | 0.92 | 0.98 | 1.58 | H = 38.66 |
| (0.88–0.97) | (0.89–0.99) | (1.5–1.74) | p < 0.0001 | |
| 11-Keto-androsterone | 0.16 | 0.16 | 0.18 | H = 3.81 |
| (0.12–0.19) | (0.13–0.19) | (0.17–0.20) | p < 0.15 | |
| 11-Hydroxy-androsterone | 0.38 | 0.35 | 0.34 | H = 4.75 |
| (0.34–0.44) | (0.29–0.44) | (0.31–0.38) | p < 0.09 | |
| 11-Hydroxy-etiocholanolone | 0.19 | 0.16 | 0.19 | H = 4.05 |
| (0.16–0.22) | (0.15–0.19) | (0.19–0.21) | p < 0.13 | |
| Androstenetriol | 0.09 | 0.09 | 0.09 | H = 2.35 |
| (0.07–0.1) | (0.07–0.11) | (0.08–0.13) | p < 0.31 | |
| Pregnanetriol | 1.34 | 1.3 | 1.43 | H = 6.25 |
| (1.13–1.53) | (1.06–1.55) | (1.37–1.58) | p < 0.07 | |
| Tetrahydro-11-deoxycortisol | 0.15 | 0.18 | 0.15 | H = 3.36 |
| (0.13–0.19) | (0.16–0.22) | (0.14–0.17) | p < 0.19 | |
| 11-Keto-pregnanetriol | 0.34 | 0.31 | 0.41 | H = 9.47 |
| (0.24–0.38) | (0.26–0.36) | (0.36–0.45) | p < 0.09 | |
| Pregnenetriol | 0.22 | 0.24 | 0.26 | H = 9.33 |
| (0.18–0.25) | (0.18–0.24) | (0.24–0.3) | p < 0.009 | |
| Tetrahydrocortisone | 3.45 | 3.26 | 2.18 | H = 34.92 |
| (3.12–3.57) | (3.0–3.56) | (2.11–2.35) | p < 0.0001 | |
| Tetrahydro-11-dehydrocorticosterone | 0.31 | 0.27 | 0.27 | H = 9.09 |
| (0.28–0.34) | (0.25–0.33) | (0.25–0.29) | p < 0.07 | |
| Tetrahydrocorticosterone | 0.42 | 0.76 | 1.82 | H =50.65 |
| (0.28–0.49) | (0.63–0.95) | (1.72–1.98) | p < 0.0001 | |
| allo-Tetrahydrocorticosterone | 0.3 | 0.27 | 0.33 | H =3.03 |
| (0.23–0.31) | (0.18–0.41) | (0.28–0.40) | p < 0.22 | |
| Tetrahydrocortisol | 1.98 | 2.46 | 3.51 | H = 51.34 |
| (1.78–2.05) | (2.31–2.82) | (3.20–3.71) | p < 0.0001 | |
| allo-Tetrahydrocortisol | 0.85 | 1.08 | 1.86 | H = 34.92 |
| (0.72–1.02) | (0.83–1.23) | (1.74–2.01) | p < 0.0001 | |
| α-Cortol | 0.68 | 0.88 | 1.58 | H = 50.49 |
| (0.63–0.74) | (0.75–1.04) | (1.45–1.78) | P < 0.0001 | |
| (α + β)-Cortolone | 0.53 | 0.54 | 0.45 | H = 5.69 |
| (0.44–0.67) | (0.45–0.61) | (0.39–0.47) | P < 0.06 |