Table 3.
Multivariate logistic regression analysis of four positive SNPs.
| Gene | SNPs | Genotypes/Alleles | PASI < 75 | PASI ≥ 75 | Adjusted OR 1 [95% CI] | p Value |
|---|---|---|---|---|---|---|
| n = 100 | n = 66 | |||||
| CRB2 | rs1105223 | TT, n (%) | 40 (42.6) | 23 (37.1) | 1.00 | |
| CT, n (%) | 31 (33) | 33 (53.2) | 2.012 [0.710–5.706] | 0.188 | ||
| CC, n (%) | 23 (24.4) | 6 (9.7) | 4.098 [1.461–11.493] | 0.007 | ||
| CT/CC, n (%) | 54 (57.4) | 39 (62.9) | 1.363 [0.679–2.735] | 0.383 | ||
| TT/CT, n (%) | 71 (75.5) | 56 (90.3) | 0.588 [0.363–0.955] | 0.032 | ||
| T, n (%) | 111 (59) | 79 (63.7) | 1.00 | |||
| C, n (%) | 77 (41) | 45 (36.3) | 1.118 [0.687–1.820] | 0.652 | ||
| ANKLE1 | rs11086065 | AA, n (%) | 33 (33.7) | 36 (56.3) | 1.00 | |
| AG, n (%) | 50 (51) | 22 (34.3) | 2.552 [0.876–7.439] | 0.086 | ||
| GG, n (%) | 15 (15.3) | 6 (9.4) | 0.905 [0.303–2.700] | 0.858 | ||
| AG/GG, n (%) | 65 (66.3) | 28 (43.8) | 2.756 [1.415–5.368] | 0.003 | ||
| AA/AG, n (%) | 83 (84.7) | 58 (90.6) | 0.815 [0.485–1.369] | 0.439 | ||
| A, n (%) | 116 (59.2) | 94 (73.4) | 1.00 | |||
| G, n (%) | 80 (40.8) | 34 (26.6) | 1.939 [1.171–3.210] | 0.010 | ||
| ARHGEF3 | rs3821414 | TT, n (%) | 51 (51) | 18 (27.3) | 1.00 | |
| CT, n (%) | 39 (39) | 34 (51.5) | 0.253 [0.095–0.675] | 0.006 | ||
| CC, n (%) | 10 (10) | 14 (21.2) | 0.568 [0.222–1.451] | 0.237 | ||
| CT/CC, n (%) | 49 (49) | 48 (72.7) | 0.386 [0.194–0.765] | 0.006 | ||
| TT/CT, n (%) | 90 (90) | 52 (78.8) | 1.593 [1.024–2.479] | 0.039 | ||
| T, n (%) | 141 (70.5) | 70 (53) | 1.00 | |||
| C, n (%) | 59 (29.5) | 62 (47) | 0.487 [0.305–0.779] | 0.003 | ||
| SFRP4 | rs1802073 | GG, n (%) | 14 (14) | 7 (10.6) | 1.00 | |
| GT, n (%) | 60 (60) | 28 (42.4) | 0.483 [0.167–1.394] | 0.178 | ||
| TT, n (%) | 26 (26) | 31 (47) | 0.402 [0.199–0.812] | 0.011 | ||
| GT/TT, n (%) | 86 (86) | 59 (89.4) | 0.797 [0.296–2.149] | 0.797 | ||
| GG/GT, n (%) | 74 (74) | 35 (53) | 2.400 [1.226–4.696] | 0.011 | ||
| G, n (%) | 88 (44) | 42 (31.8) | 1.00 | |||
| T, n (%) | 112 (56) | 90 (68.2) | 0.612 [0.380–0.984] | 0.043 |
1 adjusted for age, gender and BMI. Bold and italics in p value mean the significant result.