Valproate (VPA) reduces thapsigargin (TG)-induced apoptosis in SH-SY5Y cells. (A) The protocol of cell viability assay performed in this study. Cells were divided into four groups: the control group; the TG group; the TG and VPA group; the VPA group; (B) MTT assay result of VPA-treated SH-SY5Y cells exposed to TG. * p < 0.05 versus the TG group, n = 6; (C) Induction of apoptosis in human SH-SY5Y cells was determined by flow cytometry after treatment with TG, TG and VPA, and VPA; (D) The percentage of apoptotic cells in the treatment groups was calculated, ** p < 0.01 versus the control group, n = 3.