Table A4.
Translational stages of research on proteins investigated in parallel in studies which mainly focus on cells.
| Biomarker Abbreviation | Biomarker | Membrane or Secreted Protein | Gene | Gene ID | Total Number of Articles | Basic Research | Proof of Concept | Comparison of Methods | Basic Predictive Research | Basic Prognostic Research | Prognostic Validation | Observational | Trials | Health Economic Analyses |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HER2 | Human epidermal growth factor receptor 2 | Membrane | MUC1 | 4582 | 3 | 2 | 1 | |||||||
| pFAK | phosphorylated-focal adhesion kinase | Membrane | PTK2 | 5747 | 1 | 1 | ||||||||
| CA15-3 | CA15-3 , produced by MUC1 | Secreted | MUC1 | 4582 | 17 | 1 | 2 | 4 | 4 | 1 | 5 | |||
| CAIX | Carbonic anhydrase IX | Secreted | CA9 | 768 | 1 | 1 | ||||||||
| CEA | Carcinoembryonic antigen related cell adhesion molecule | Secreted | CEACAM5 | 1048 | 6 | 1 | 1 | 1 | 1 | 1 | 1 | |||
| CXCL1 | chemokine (C-X-C Motif) Ligand-1 | Secreted | CXCL1 | 2919 | 1 | 1 | ||||||||
| Fibrinogen | Fibrinogen | Secreted | FGA | 2243 | 1 | 1 | ||||||||
| LDHA | Lactate dehydrogenase | Secreted | LDHA | 3939 | 2 | 1 | 1 | |||||||
| M30 | Cytokeratin 18 fragments | Secreted | KRT18 | 3875 | 3 | 1 | 2 | |||||||
| P53 | Tumor Protein P53 | Secreted | TP53 | 7157 | 1 | 1 | ||||||||
| TGF-B | Transcription Growth Factor Beta 1 | Secreted | TGFB1 | 7040 | 1 | 1 | ||||||||
| TIMP-1 | TIMP metallopeptidase inhibitor 1 | Secreted | TIMP1 | 7076 | 1 | 1 | ||||||||
| Bcl-2 | BCL2 apoptosis regulator | Secreted | BCL2 | 596 | 1 | 1 |