Table A6.
Translational stage of genes investigated in studies that focus on circulating DNA.
| Biomarker Abbreviation | Biomarker | Gene | Gene ID | Total Number of Articles | Basic Research | Proof of Concept | Comparison of Methods | Basic Predictive Research | Basic Prognostic Research | Prognostic Validation | Observational | Trials | Health Economic Analyses |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKR1B1 | Aldo-keto reductase family 1 | AKR1B1 | 231 | 1 | 1 | ||||||||
| AKT1 | AKT serine threonine kinase 1 | AKT1 | 207 | 1 | 1 | ||||||||
| APC | APC, WNT signaling pathway | APC | 324 | 1 | 1 | ||||||||
| ARHGEF7 | Rho guanine nucleotide exchange factor 7 | ARHGEF7 | 8874 | 1 | 1 | ||||||||
| COL6A2 | Collagen type VI α 2 chain | COL6A2 | 1292 | 1 | 1 | ||||||||
| ESR1 | Estrogen Receptor 1 | ESR1 | 2099 | 4 | 4 | ||||||||
| FGFR1 | Fibroblast growth factor receptor 1 | FGFR1 | 2260 | 1 | 1 | ||||||||
| FGFR2 | Fibroblast growth factor receptor 2 | FGFR2 | 2263 | 1 | 1 | ||||||||
| GPX7 | Glutathione peroxidase 7 | GPX7 | 2882 | 1 | 1 | ||||||||
| GSTP1 | Glutathione S-transferase pi1 | GSTP1 | 2950 | 1 | 1 | ||||||||
| HER2 | Human epidermal growth factor receptor 2 | ERBB2 | 2064 | 2 | 2 | ||||||||
| HIST1H3C | Histone cluster 1 H3 family member C | HIST1H3C | 8352 | 1 | 1 | ||||||||
| HOXB4 | Homeobox B4 | HOXB4 | 3214 | 1 | 1 | ||||||||
| IDH2 | Isocitrate dehydrogenase 2 | IDH2 | 3418 | 1 | 1 | ||||||||
| KU86 | X-ray repair cross complementin 5 | XRCC5 | 7520 | 1 | 1 | ||||||||
| PIK3CA | Phosphalidylinositol-4,5-bisphosphate 3 kinase catalytic subunit α | PIK3CA | 5290 | 6 | 6 | ||||||||
| PTEN | Phosphatase and tensin homolog | PTEN | 5728 | 1 | 1 | ||||||||
| RARβ2 gene | Retinoic acid receoptor beta | RARB | 5915 | 1 | 1 | ||||||||
| RASGRF2 | Ras protein specific guanine nucleotide-releasing factor 2 | RASGRF2 | 5924 | 1 | 1 | ||||||||
| RASSF1A | Ras association domain family member 1 | RASSF1 | 11186 | 6 | 1 | 5 | |||||||
| Stratifin | Stratifin | SFN | 2810 | 1 | 1 | ||||||||
| TM6SF1 | Transmembrane 6 superfamily member 1 | TM6F1 | 53346 | 1 | 1 | ||||||||
| TMEFF2 | Transmembrane protein with EGF like and two follistatin like domains 2 | TMEFF2 | 23671 | 1 | 1 | ||||||||
| TP53 | Tumor Protein P53 | TP53 | 7157 | 5 | 4 | 1 | |||||||
| WGA | Whole genome amplification | * | * | 1 | 1 |
* Whole genome amplification has been performed once. No specific gene or gene ID has been reported as multiple genes can be identified. However, in the study that presented whole genome amplification, no further gene information has been presented.