Skip to main content
. 2017 Feb 9;18(2):366. doi: 10.3390/ijms18020366

Figure 6.

Figure 6

Schematic drawing of the middle region of the HPV16 genome. HPV16 3′-splice site SA3358, used by both early and late mRNAs is indicated. The exclusively late 5′-splice site SD3632 with hnRNP D binding to upstream splicing silencer elements to suppress SD3632 [41]. heterogenous nuclear ribonuclear protein C (hnRNP C), HuR, polypyrimidine tract binding protein (PTB) and Fip1 binding to the HPV16 early untranslated region (UTR) are indicated [6,9,22,43,48,51]. hnRNP H binds to sequences downstream of the HPV16 early polyadenylation signal pAE to promote polyadenylation at pAE [6,9,46,47]. Double arrow represents the interactions between hnRNP C that binds to the HPV16 early UTR, and hnRNP D that binds to the splicing silencers upstream of SD3632 [9,48]. The interaction of hnRNP C with hnRNP D activates HPV16 late 5′-splice site SD3632 and induces splicing from SD3632 to SA5639 and thereby activates production of the spliced, major late L1 mRNAs [9,48].