Table 3.
Fold changes in significantly differentially expressed genes involved in kidney development in the kidneys of offspring at two weeks of age exposed to maternal caloric restriction (CR), streptozotocin (STZ)-induced diabetes, high-fructose (HF) diet, and high salt (HS) intake.
| Gene ID | Gene Symbol | CR | STZ | HF | HS |
|---|---|---|---|---|---|
| Expansion and survival of renal stem cells | |||||
| ENSRNOG00000012278 | Fgf10 | 0.52 | 0.38 | 0.55 | 0.87 |
| Formation and extension of the primary nephric duct | |||||
| ENSRNOG00000012819 | Gdnf | 2563 | 1508 | 1836 | 1362 |
| ENSRNOG00000008430 | Spry3 | ND | 123 | 1.04 | 278 |
| ENSRNOG00000022777 | Six1 | 1.58 | 0.4 | 2.64 | 1.55 |
| ENSRNOG00000026053 | Grem1 | 0.57 | 0.47 | 1.21 | 0.83 |
| Initiation of metanephric development | |||||
| ENSRNOG00000003807 | Wnt9b | 0.75 | 1.27 | 0.49 | 0.85 |
| ENSRNOG00000015982 | Wnt11 | 1.18 | 3.37 | 1.29 | 1.3 |
| ENSRNOG00000007002 | Lif | 0.36 | 0.64 | 0.95 | 1.12 |
| ENSRNOG00000017392 | Fgf2 | 2.07 | 2.9 | 1.54 | 0.82 |
| ENSRNOG00000020792 | Etv4 | 0.94 | 2.66 | 1.7 | 1.53 |
| Mesoderm patterning | |||||
| ENSRNOG00000004210 | Osr1 | 0.27 | 0.46 | 0.61 | 0.57 |
| ENSRNOG00000021276 | Bmp2 | 1.72 | 2.39 | 0.86 | 1.05 |
| ENSRNOG00000000556 | Nodal | ND | ND | ND | 242 |
| Nephron development | |||||
| ENSRNOG00000004517 | Igf1 | 0.55 | 0.44 | 0.77 | 0.64 |
| ENSRNOG00000004346 | Notch3 | 1.18 | 2.09 | 0.83 | 1.06 |
ND = not detectable; Significant results are highlighted in bold.