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EGFR and its splicing variants. Alternative splicing of EGFR generates eight variants including those that encode soluble isoforms, sEGFRv2, sEGFRv3, and sEGFRv4, and those can encode non-soluble isoforms, mLEEK, EGFRvA, EGFRvIII, EGFRvIVa, and EGFRvIVb. For each splice variant, the number of exons (upper) and functional domains of the protein (lower) are represented. L: ligand binding, CR: Cysteine-Rich.
