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. 2017 Feb 15;18(2):413. doi: 10.3390/ijms18020413

Figure 1.

Figure 1

Azoxymethane (AOM)-induced colonic preneoplastic lesions aberrant crypt foci (ACF) and β-catenin accumulated crypts (BCACs) in male C57BL/KsJ-db/db mice. Representative pictures of AOM-induced colonic preneoplastic lesions; (A) ACF revealed by methylene blue staining and (B) BCACs stained immunohistochemically for β-catenin. Scale bars, 200 µm (left); 50 µm (right); (C) The numbers of ACF and BCACs observed in each group. Large ACFs, ACFs with four or more aberrant crypts. Each column represents the mean ± SD (n = 6 for each group). * p < 0.05 vs. pentoxifylline (PTX)-untreated control group.