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. 2017 Feb 20;18(2):432. doi: 10.3390/ijms18020432

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Apoptosis- and splicing-associated protein (ASAP) complex is involved in Polycomb silencing of FLC expression during vernalization. During vernalization, VAL1/2 bind the RY-1/2 cis-elements in the first intron of FLC, interact with components of the conserved ASAP complex, which consists of SIN3-associated protein 18 (SAP18), ACINUS and SR45, and further recruit PHD-PRC2. This transcriptional repression complex triggers histone deacetylation in FLC chromatin and leads to FLC transcriptional silencing in a sequence specific manner during vernalization. HDA: histone deacetylase. PRC2: polycomb repressive complex 2. VIN3: vernalization insensitive 3. VRN: vernalization. VAL: viviparous1/ABI3-like.