Table 4.

Differentially expressed proteins in the hippocampus mitochondria of apoE^−/− group vs. wild type animals (p < 0.05, n = 3).

No.	Protein	UniProtKB Accession No.	Unique Peptides	Total Peptides	Fold Change
1	Coronin-2B	Q8BH44	2	3	1.73
2	Protein deglycase DJ-1	Q99LX0	5	20	1.32
3	Synaptoporin	Q8BGN8	4	8	1.23
4	ATP synthase subunit δ, mitochondrial	Q9D3D9	3	18	1.23
5	Spectrin β chain, erythrocytic	P15508	3	9	1.23
6	MICOS complex subunit Mic25	Q91VN4	2	3	1.21
7	Ubiquitin-60S ribosomal protein L40	P62984	4	51	1.21
8	Tubulin α-1 chain	A2AQ07	7	33	1.17
9	Tropomyosin α-3 chain	P21107	3	16	1.17
10	Paralemmin-1	Q9Z0P4	7	33	1.16
11	Disks large homolog 4	Q62108	5	19	1.14
12	Pyruvate dehydrogenase E1 component subunit β, mitochondrial	Q9D051	16	86	1.14
13	Creatine kinase B-type	Q04447	19	306	1.11
14	Calcium/calmodulin-dependent protein kinase type II subunit α	P11798	25	329	1.10
15	Tubulin β-4 B chain	P68372	11	249	1.09
16	Heat shock cognate 71 kDa protein	P63017	37	351	1.08
17	Hexokinase-1	P17710	33	246	1.07
18	Spectrin β chain, non-erythrocytic 1	Q62261	72	351	1.07
19	ADP/ATP translocase 1	P48962	22	217	−1.11
20	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit β-1	P62874	12	134	−1.11
21	Calcium-dependent secretion activator 1	Q80TJ1	16	56	−1.14
22	Fumarate hydratase, mitochondrial	P97807	10	38	−1.15
23	Glutathione S-transferase Mu 1	P10649	15	76	−1.15
24	Dihydropyrimidinase-related protein 1	P97427	8	32	−1.15
25	Thioredoxin	P10639	3	11	−1.18
26	Ras-related protein Rab-1A	P62821	6	46	−1.20
27	Actin-related protein 2	P61161	6	13	−1.24
28	Mitochondrial 2-oxoglutarate/malate carrier protein	Q9CR62	6	16	−1.26
29	Heterogeneous nuclear ribonucleoprotein K	P61979	3	13	−1.28
30	α-endosulfine	P60840	2	3	−1.30
31	Calcium/calmodulin-dependent protein kinase type IV	P08414	2	4	−1.34
32	Guanine nucleotide-binding protein G(i) subunit α-2	P08752	4	13	−1.37
33	Myelin basic protein	P04370	11	138	−1.43
34	2′,3′-cyclic-nucleotide 3′-phosphodiesterase	P16330	32	210	−1.47