Figure 5.

Expression of brain-derived neurotrophic factor (BDNF), phosphorylated-tropomyosin-related kinase B (p-TrkB), TrkB (total), phosphorylated-Akt (p-AKT), Akt, phosphorylated-CREB (cAMP responsive element-binding protein), and CREB in the ipsilateral hemisphere excluding the infarct area. (A) Western blot analysis of p-TrkB, TrkB (total), p-Akt, Akt, p-CREB, CREB and BDNF. Protein expression levels were normalized with α-tubulin; (B) Quantification of BDNF mRNA expression in the ipsilateral hemisphere excluding the infarct area. BDNF mRNA expression in the 20 Hz rTMS and iTBS groups was significantly higher than that observed in the control group at seven and 14 days after MCAO, while there were no difference between the 20 Hz rTMS and iTBS groups (* p < 0.01).