Figure 5.

Tissue-specificity in sexual dimorphism in the expression of GRs, Hsd11b2 and several MR-regulated target genes: example in the lung of adult (M3) mice. GR (A); Sgk1 (B); Gilz (C); and Hsd11b2 (D) pulmonary relative mRNA expressions in adult mice (M3: 3-month-old) were determined using RT-qPCR. Results, expressed as the ratio of attomoles of specific gene per femtomole of ribosomal 18S, normalized to the expression of male mice arbitrarily set at 1, correspond to mean ± SEM of three independent experiments comprising at least 6 male and 6 female lungs each. *** p < 0.001.