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. 2017 Feb 21;18(2):460. doi: 10.3390/ijms18020460

Figure 4.

Figure 4

Effects of CCAR1 knockdown on xenograft gastric cancer formation. (A) Control or -shCCAR1-expressing AGS cells were injected subcutaneously into athymic nude mice to establish tumors. Tumor sizes were measured and depicted as tumor volume, and tumor growth curves were plotted accordingly. The symbol *** indicates p < 0.001; (B) Representative images showing subcutaneously injected xenograft tumors in nude mice at day 65 post subcutaneous injection. Black arrows indicate xenograft tumors derived from Control AGS cells, and white arrows indicate xenograft tumors derived from CCAR1 shRNA-expressing AGS cells; (C) Representative images showing respective xenograft tumors at day 65 post subcutaneous injection (n = 3 per group). Data are presented as the mean with error bars representing the S.D; (D) Representative images of H&E and terminal deoxynecleotidyl transferase-mediated dUTP nick-end-labeling (TUNEL) staining (brown) of xenografts. Scale bar: 40 µm.