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. 2017 Feb 22;18(2):471. doi: 10.3390/ijms18020471

Figure 6.

Figure 6

Effects of Gomisin N on the melanogenic pathways in rapamycin-stimulated MNT-1 cells. Protein levels of tyrosinase (A,B), MITF (A,C), TRP-1 (A,D), and TRP-2 (A,E) were measured Western blot analysis in MNT-1 cells after co-treatment with 10, 20, or 30 µM of Gomisin N and 100 nM of rapamycin for 72 h, α-Tubulin was used as a loading control. Densitometric data are presented as the mean ± SEM of three independent experiments. ** p < 0.01, and *** p < 0.001 versus the rapamicin-treated control (Rapa). # p < 0.05, ## p < 0.01, and ### p < 0.001 versus the untreated control (C).