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. Author manuscript; available in PMC: 2017 Oct 12.
Published in final edited form as: Nano Lett. 2016 Sep 13;16(10):6303–6310. doi: 10.1021/acs.nanolett.6b02670

Figure 3. Magnetothermal activation: coil design and parameter determination for magnetically induced release.

Figure 3

(a) Optimal AMF parameters were evaluated by calorimetric measurements. Fit line interpolated using a power law valid for field strength magnitudes between 0 and 20 kA/m (n=3, SEM). Inset: fluid temperature increase during 30 s of AMF exposure at 515 kHz and 15 kA/m (n = 5). (b) Technical drawing of coil with ferromagnetic core utilized in studies. Inset shows the distribution of the specific loss power (SLP) for 25 nm particles at 515 kHZ across the 12.5 mm wide gap. SLP values were derived based on the interpolation of the measurements shown in (a) at 515 kHZ and varying field amplitude. (c) Infrared thermal camera measurements of heat dissipation in the coil gap during a duty cycle of 40 s on time and 240 s off. (d) Liposomes prepared with quenched calcein solution and with and without MNPs were exposed to an AMF sequence (515 kHz, 15 kA/m for 40 s). Fluorescence release was quantified. The release profiles were compared to fluorescence signal increase by the addition of TritonX, which destroys the liposomal structure (n ≥ 2, SEM).