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. 2016 Nov 18;24(3):409–420. doi: 10.1038/cdd.2016.135

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Chromatin remodeling in enhancers. (a) Statistical summary of each category of enhancers defined by HM state in NSCs changing to other categories in neurons. (b) Nucleosome organization in the regions flanking NDRs within neuron enhancers. Left heatmaps show clustering view of nucleosome occupancy in ±1 kb regions centering at NDRs in neuron enhancers. Right curve plots show the composite distribution of nucleosomes to the midpoint of the evicted nucleosomes in NDRs in neuron enhancers. (c) ChIP-qPCR validation for evicted nucleosomes in the enhancers of selected genes in neurons (**P<0.01, T-test) (d) Expression levels of genes associated with the three clusters of enhancers in (b) (**P<0.01, T-test). (e) Synergistic HM changes in enhancers and promoters. Upregulated genes have increased expression level as En.K27ac signals increase in neurons. Downregulated genes have decreased expression level as En.K27ac signals decrease in neurons. Genes are ordered in a descending order by the log 2-transformed fold change of En.K27ac. Prefixes En indicates enhancer and Pro indicates promoter. (f) Enriched GO terms for the upregulated (pink) and downregulated (green) genes in (e)