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. 2016 Jan 29;4(1):3. doi: 10.3390/biomedicines4010003

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© 2015 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combination cytotoxicity on AMN3 cells. (a) The cytotoxic effect of 5-FU, NDV, or both, on AMN3 cell proliferation. The cells were treated with 5-FU (5 µg in two-fold serial dilutions up to 0.039 µg/mL), NDV (128 HUA with two-fold serial dilutions) or a combination of the two. The results for the treated groups are expressed as the cell proliferation rate compared to untreated control cells grown at identical conditions; (b) isobologram analysis shows the synergism between NDV and 5-FU at the highest five doses and antagonism at three doses (point 1 and 2 value above 2 and for that will not be shown in the figure limits as they considered as extremely antagonized); and (c) table showing the combination index data for each dose of the combination points used.

Combination cytotoxicity on AMN3 cells. (a) The cytotoxic effect of 5-FU, NDV, or both, on AMN3 cell proliferation. The cells were treated with 5-FU (5 µg in two-fold serial dilutions up to 0.039 µg/mL), NDV (128 HUA with two-fold serial dilutions) or a combination of the two. The results for the treated groups are expressed as the cell proliferation rate compared to untreated control cells grown at identical conditions; (b) isobologram analysis shows the synergism between NDV and 5-FU at the highest five doses and antagonism at three doses (point 1 and 2 value above 2 and for that will not be shown in the figure limits as they considered as extremely antagonized); and (c) table showing the combination index data for each dose of the combination points used.