Figure 3.

Decreased but persistent FMISO hypoxic volume in recurrent high grade glioma concurrent with bevacizumab therapy. FMISO PET/MR imaging obtained simultaneously 7 days prior to (A) and 36 days following antiangiogenesis therapy (B) demonstrates response to therapy characterized by decreased volume of contrast enhancement (top row) and nonenhancing FLAIR hyperintense mass (middle row) without evidence of reduced diffusion (adc map, bottom row). Unprocessed (bottom) and fused FMISO PET imaging (baseline, middle left; follow-up, middle right) demonstrates decreased but persistent tumor hypoxic volume predominately within the enhancing component. Follow-up MR imaging did not demonstrate the development of nonenhancing reduced diffusion mass at any point of therapy.