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. 2016 Dec 1;4(4):28. doi: 10.3390/biomedicines4040028

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Accumulated data on morphological and molecular features of native retinal pigment epithelium (RPE) cells and those at the beginning of natural reprogramming to neuronal and glial cells of regenerating retina [6,7,11,12,13,14,17,18,19,20,21,22,23,24]. (A) RPE cells (thin white arrows) in the RPE layer of the newt Pleurodeles waltl; (B) RPE cell that left its layer and stays at the beginning of reprogramming (thick white arrow); Scale bar: 100 µm. See details in the text. Down- (↓) and up- (↑) regulation of gene/protein expression.