Table 3. Prognostic and redictive value of necrosis for overall survival.
|
Univariable models |
Multivariable model (prognostic) |
Multivariable model (predictive) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | HR | 95% CI | P-value | N | HR | 95% CI | P-value | N | HR | 95% CI | P-value | ||||
| Sex | |||||||||||||||
| Male (ref) | 183 | 1.00 | 172 | 1.00 | 172 | 1.00 | |||||||||
| Female | 47 | 0.84 | 0.55 | 1.29 | 0.43 | 46 | 0.81 | 0.51 | 1.27 | 0.36 | 46 | 0.82 | 0.52 | 1.29 | 0.38 |
| Age (years) | 230 | 1.02 | 1.00 | 1.05 | 0.05 | 218 | 1.02 | 1.00 | 1.05 | 0.07 | 218 | 1.02 | 1 | 1.05 | 0.07 |
| WHO performance status | |||||||||||||||
| 0 (ref) | 146 | 1.00 | 142 | 1.00 | 142 | 1.00 | |||||||||
| 1–2 | 84 | 1.79 | 1.28 | 2.50 | 0.001 | 76 | 1.55 | 1.08 | 2.24 | 0.02 | 76 | 1.54 | 1.06 | 2.21 | 0.02 |
| Stage | |||||||||||||||
| 2 (ref) | 202 | 1.00 | 191 | 1.00 | 191 | 1.00 | |||||||||
| 3–4 | 28 | 1.34 | 0.83 | 2.15 | 0.23 | 27 | 1.00 | 0.58 | 1.71 | 0.99 | 27 | 0.99 | 0.58 | 1.7 | 0.98 |
| Residual mass after resection* | |||||||||||||||
| No (ref) | 151 | 1.00 | 151 | 1.00 | 151 | 1.00 | |||||||||
| Yes | 67 | 2.10 | 1.48 | 3.00 | <0.001 | 67 | 2.04 | 1.38 | 3.02 | <0.001 | 67 | 2.02 | 1.37 | 3 | <0.001 |
| Haemoglobin, g dl−1 | 230 | 0.89 | 0.81 | 0.98 | 0.02 | 218 | 0.89 | 0.80 | 0.99 | 0.03 | 218 | 0.89 | 0.8 | 0.98 | 0.03 |
| Cis | |||||||||||||||
| Absent (ref) | 185 | 1.00 | 175 | 1.00 | 175 | 1.00 | |||||||||
| Present | 45 | 1.08 | 0.72 | 1.63 | 0.71 | 43 | 1.26 | 0.80 | 1.98 | 0.32 | 43 | 1.26 | 0.8 | 1.98 | 0.32 |
| Necrosis | |||||||||||||||
| Absent (ref) | 142 | 1.00 | 134 | 1.00 | Included in interaction below | ||||||||||
| Present | 88 | 0.97 | 0.69 | 1.37 | 0.88 | 84 | 0.86 | 0.59 | 1.25 | 0.44 | |
||||
| Treatment | |||||||||||||||
| Radiotherapy (ref) | 109 | 1.00 | 107 | 1.00 | Included in interaction below | ||||||||||
| Chemoradiotherapy | 121 | 0.84 | 0.61 | 1.18 | 0.32 | 111 | 0.81 | 0.56 | 1.15 | 0.24 | |
||||
| Necrosis absent: treatment | |||||||||||||||
| Radiotherapy (ref) | Not applicable, model without interaction | 68 | 1.00 | ||||||||||||
| Chemoradiotherapy | |
66 |
0.88 |
0.56 |
1.37 |
0.56 |
|||||||||
| Necrosis present: treatment | |||||||||||||||
| Radiotherapy (ref) | Not applicable, model without interaction | 39 | 1.00 | ||||||||||||
| Chemoradiotherapy | 45 | 0.71 | 0.4 | 1.26 | 0.24 | ||||||||||
Hazard ratios for all covariates in the models are included. Univariable models present unadjusted estimates for necrosis treatment, and all other prognostic factors; Multivariable model (prognostic) provides the prognostic value for necrosis adjusted by other relevant factors; Multivariable model (predictive) model provides predictive value for necrosis adjusted for other important factors (test for interaction necrosis:treatment, P-value 0.56).