Table 5. Composite lifestyle score and gastric adenocarcinoma risk among subjects with measurement of Helicobacter pylori infection (CagA) status, the Singapore Chinese Health Study, 1993–2014.
|
All subjects |
H. pylori-positive onlya |
||||
|---|---|---|---|---|---|
| Characteristics | Ca/Co | OR (95% CI)b | OR (95% CI)c | Ca/Co | OR (95% CI)b |
| All subjects | 133/389 | 128/329 | |||
| Composite score | |||||
| 0/1/2 | 26/46 | 1.00 (reference) | 1.00 (reference) | 24/39 | 1.00 (reference) |
| 3 | 47/112 | 0.77 (0.43–1.40) | 0.78 (0.43–1.42) | 46/92 | 0.78 (0.42–1.46) |
| 4 | 44/161 | 0.44 (0.24–0.81) | 0.43 (0.23–0.81) | 43/139 | 0.42 (0.21–0.82) |
| 5 | 16/70 | 0.37 (0.16–0.82) | 0.36 (0.16–0.82) | 15/59 | 0.34 (0.15–0.80) |
| Ptrend | 0.017 | 0.017 | 0.019 | ||
| PAR (95% CI) | 0.62 (0.26, 0.82) | 0.62 (0.27, 0.83) | 0.64 (0.28, 0.84) | ||
| Composite Z-score | |||||
| 1st Quartile | 48/110 | 1.00 (reference) | 1.00 (reference) | 46/94 | 1.00 (reference) |
| 2nd Quartile | 28/89 | 0.71 (0.41–1.22) | 0.68 (0.40–1.19) | 28/76 | 0.70 (0.39–1.23) |
| 3rd Quartile | 34/90 | 0.79 (0.46–1.38) | 0.80 (0.46–1.41) | 32/77 | 0.75 (0.42–1.35) |
| 4th Quartile | 23/100 | 0.53 (0.28–0.98) | 0.56 (0.29–1.06) | 22/82 | 0.54 (0.27–1.05) |
| Ptrend | 0.068 | 0.117 | 0.094 | ||
| Cardia cases | 24/69 | 21/60 | |||
| Composite score | |||||
| 0/1/2 | 6/8 | 1.00 (reference) | 1.00 (reference) | 5/8 | 1.00 (reference) |
| 3 | 7/22 | 0.46 (0.09–2.42) | 0.45 (0.08–2.41) | 7/17 | 0.58 (0.10–3.29) |
| 4 | 9/27 | 0.28 (0.06–1.30) | 0.28 (0.06–1.33) | 8/25 | 0.33 (0.06–1.68) |
| 5 | 2/12 | 0.20 (0.02–1.63) | 0.20 (0.02–1.61) | 1/10 | 0.11 (0.01–1.57) |
| Ptrend | 0.074 | 0.075 | 0.065 | ||
| Composite Z-score | |||||
| 1st Quartile | 11/23 | 1.00 (reference) | 1.00 (reference) | 10/20 | 1.00 (reference) |
| 2nd Quartile | 4/15 | 0.47 (0.12–1.84) | 0.47 (0.12–1.87) | 4/13 | 0.53 (0.13–2.17) |
| 3rd Quartile | 5/17 | 0.29 (0.06–1.43) | 0.29 (0.06–1.44) | 4/14 | 0.33 (0.07–1.65) |
| 4th Quartile | 4/14 | 0.62 (0.15–2.59) | 0.62 (0.15–2.59) | 3/13 | 0.42 (0.08–2.24) |
| Ptrend | 0.296 | 0.297 | 0.195 | ||
| Non-cardia cases | 88/253 | 87/212 | |||
| Composite score | |||||
| 0/1/2 | 17/27 | 1.00 (reference) | 1.00 (reference) | 16/23 | 1.00 (reference) |
| 3 | 34/74 | 0.69 (0.33–1.44) | 0.73 (0.34–1.57) | 34/60 | 0.76 (0.35–1.67) |
| 4 | 27/106 | 0.31 (0.14–0.70) | 0.34 (0.14–0.79) | 27/90 | 0.35 (0.15–0.83) |
| 5 | 10/46 | 0.24 (0.08–0.70) | 0.28 (0.10–0.81) | 10/39 | 0.29 (0.10–0.85) |
| Ptrend | 0.009 | 0.023 | 0.026 | ||
| Composite Z-score | |||||
| 1st Quartile | 31/68 | 1.00 (reference) | 1.00 (reference) | 30/59 | 1.00 (reference) |
| 2nd Quartile | 20/58 | 0.72 (0.37–1.39) | 0.72 (0.36–1.43) | 20/49 | 0.72 (0.36–1.44) |
| 3rd Quartile | 24/59 | 0.76 (0.38–1.51) | 0.86 (0.42–1.75) | 24/50 | 0.87 (0.42–1.80) |
| 4th Quartile | 13/68 | 0.36 (0.15–0.83) | 0.44 (0.19–1.05) | 13/54 | 0.45 (0.19–1.08) |
| Ptrend | 0.030 | 0.121 | 0.139 | ||
Abbreviations: Ca=Cases; CI=confidence interval; Co=Controls; OR=odds ratio; PAR=population attributable risk.
a
H. pylori positive defined by positive serum CagA status.
b
Conditional logistic regression model adjusted for age at baseline interview (in years), baseline interview year (1993–1995, 1996–1998), father's dialect (Cantonese, Hokkien), gender, and education (no formal education, primary education, ⩾secondary education).
c
Further adjusted for serum H. pylori CagA status (positive, negative).