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. 2017 Mar 9;13(3):e1006622. doi: 10.1371/journal.pgen.1006622

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© 2017 Forés et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Structure of Drosophila CIC and CIC derivatives in which the HMG-box has been replaced by the bHLH domain of Hairy. The CIC(bHLH) and CIC(bHLH)^ΔC1 proteins are tagged with the HA epitope and are thus discernable from endogenous CIC. (B) Expression of CIC(bHLH)-HA in embryos stained with anti-HA antibody. The inset shows a higher magnification view of nuclear CIC(bHLH)-HA accumulation. (C-E) Sxl mRNA expression in female wild-type (C) and transgenic embryos expressing CIC(bHLH) (D) and CIC(bHLH)^ΔC1 (E). Sxl appears clearly repressed in both transgenic embryos.