Table 2. Influence of leptin SDS and SMA type on motor function.
MFM32 | estimatedcoeff. [95%-CI] | p-value(t-Test) | SMA—globaltest (F-Test) | |
---|---|---|---|---|
D1: standing | Leptin SD | 0.2 (-1.3–1.6) | 0.799 | |
position | SMA II vs. I | 3.2 (-1.6–8.1) | 0.183 | |
and transfers | SMA III vs. I | 56.6 (33.0–80.1) | <0.001 | <0.001 |
constant | -0.3 (-8.1–7.5) | 0.935 | ||
D2: axial and | Leptin SD | -3.6 (-7.5–0.3) | 0.066 | |
proximal | SMA II vs. I | 28.7 (8.3–49.1) | 0.007 | |
motor | SMA III vs. I | 67.8 (43.8–91.8) | <0.001 | <0.001 |
function | constant | 28.2 (3.0–53.4) | 0.029 | |
D3: distal | Leptin SD | -2.7 (-6.8–1.4) | 0.184 | |
motor | SMA II vs. I | 26.8 (-9.1–62.7) | 0.137 | |
function | SMA III vs. I | 67.4 (30.0–104.8) | 0.001 | <0.001 |
constant | 31.0 (-9.6–71.6) | 0.129 | ||
Total | Leptin SD | -1.9 (-4.2–0.3) | 0.094 | |
score | SMA II vs. I | 17.8 (2.4–33.3) | 0.025 | |
SMA III vs. I | 62.7 (42.1–83.3) | <0.001 | <0.001 | |
constant | 17.4 (-0.7–35.5) | 0.060 |
MFM32 = Motor Function Measurement32, vs. = versus; SD = Standard Deviation, coeff. = Coefficient; CI = Confidence Interval; SMA = spinal muscular atrophy