Table 1. Effects of CSDS on the behavior of male post-pubertal CD1 mice in the social interaction test.
Behavioral categories | Stress and pharmacological treatments | |||||
---|---|---|---|---|---|---|
Social Interaction ratio | Non-stressed | Stressed-resilient | Stressed-susceptible | |||
1.7 ± 0.21 | 1.5 ± 0.10 | 0.5 ± 0.06&&&### | ||||
Saline | Indomethacin | Saline | Indomethacin | Saline | Indomethacin | |
1.5 ± 0.27 | 1.9 ± 0.31 | 1.6 ± 0.15 | 1.3 ± 0.09 | 0.6 ± 0.06 | 0.5 ± 0.11 | |
Time in interaction zone | Non-stressed | Stressed-resilient | Stressed-susceptible | |||
40.7 ± 2.65 | 56.5 ± 3.17& | 56.4 ± 2.67& | ||||
Target absent | Saline | Indomethacin | Saline | Indomethacin | Saline | Indomethacin |
42 ± 3.6 | 39.4 ± 4.05 | 55.1 ± 5.13 | 58 ± 3.77 | 55,8 ± 3.06 | 57 ± 4.54 | |
Target present | Non-stressed | Stressed-resilient | Stressed-susceptible | |||
84.9 ± 4.25 | 79.8 ± 5.34 | 27.2 ± 2.97&&& | ||||
Saline | Indomethacin | Saline | Indomethacin | Saline | Indomethacin | |
82.4 ± 6.42*** | 87.4 ± 5.8*** | 84.7 ± 8.48** | 74.5 ± 6.31* | 31.9 ± 3.56*** | 22.5 ± 4.44*** | |
Time in corner zones | Non-stressed | Stressed-resilient | Stressed-susceptible | |||
18.6 ± 1.8 | 13 ± 1.25& | 14 ± 1.63 | ||||
Target absent | Saline | Indomethacin | Saline | Indomethacin | Saline | Indomethacin |
18 ± 1.78 | 19.3 ± 3.22 | 13.8 ± 1.82 | 12.1 ± 1.77 | 14.8 ± 2.4 | 13.3 ± 2.3 | |
Target present | Non-stressed | Stressed-resilient | Stressed-susceptible | |||
6.8 ± 1.07 | 9.2 ± 2.07 | 28.6 ± 4.83&&&### | ||||
Saline | Indomethacin | Saline | Indomethacin | Saline | Indomethacin | |
7.3 ± 1.77** | 6.3 ± 1.27* | 9.8 ± 3.25 | 8.6 ± 2.61 | 30.7 ± 8.58* | 26.5 ± 4.89* |
Non-stressed (n = 20) = Non-stressed-Saline (n = 10) + Non-stressed-Indomethacin (n = 10); Stressed-resilient (n = 23) = Stressed-resilient-Saline (n = 12) + Stressed-resilient-Indomethacin (n = 11); Stressed-susceptible (n = 20) = Stressed-susceptible-Saline (n = 10) + Stressed-susceptible-Indomethacin (n = 10). Values are expressed as means (±SEM).
&p<0.05
&&&p<0.001 vs Non-stressed group
###p<0.001 vs Stressed-resilient group
*p≤0.05
**p<0.01
***p<0.001 vs target absent.