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. 2017 Mar 9;12(3):e0173182. doi: 10.1371/journal.pone.0173182

Table 1. Effects of CSDS on the behavior of male post-pubertal CD1 mice in the social interaction test.

Behavioral categories Stress and pharmacological treatments
Social Interaction ratio Non-stressed Stressed-resilient Stressed-susceptible
1.7 ± 0.21 1.5 ± 0.10 0.5 ± 0.06&&&###
Saline Indomethacin Saline Indomethacin Saline Indomethacin
1.5 ± 0.27 1.9 ± 0.31 1.6 ± 0.15 1.3 ± 0.09 0.6 ± 0.06 0.5 ± 0.11
Time in interaction zone Non-stressed Stressed-resilient Stressed-susceptible
40.7 ± 2.65 56.5 ± 3.17& 56.4 ± 2.67&
Target absent Saline Indomethacin Saline Indomethacin Saline Indomethacin
42 ± 3.6 39.4 ± 4.05 55.1 ± 5.13 58 ± 3.77 55,8 ± 3.06 57 ± 4.54
Target present Non-stressed Stressed-resilient Stressed-susceptible
84.9 ± 4.25 79.8 ± 5.34 27.2 ± 2.97&&&
Saline Indomethacin Saline Indomethacin Saline Indomethacin
82.4 ± 6.42*** 87.4 ± 5.8*** 84.7 ± 8.48** 74.5 ± 6.31* 31.9 ± 3.56*** 22.5 ± 4.44***
Time in corner zones Non-stressed Stressed-resilient Stressed-susceptible
18.6 ± 1.8 13 ± 1.25& 14 ± 1.63
Target absent Saline Indomethacin Saline Indomethacin Saline Indomethacin
18 ± 1.78 19.3 ± 3.22 13.8 ± 1.82 12.1 ± 1.77 14.8 ± 2.4 13.3 ± 2.3
Target present Non-stressed Stressed-resilient Stressed-susceptible
6.8 ± 1.07 9.2 ± 2.07 28.6 ± 4.83&&&###
Saline Indomethacin Saline Indomethacin Saline Indomethacin
7.3 ± 1.77** 6.3 ± 1.27* 9.8 ± 3.25 8.6 ± 2.61 30.7 ± 8.58* 26.5 ± 4.89*

Non-stressed (n = 20) = Non-stressed-Saline (n = 10) + Non-stressed-Indomethacin (n = 10); Stressed-resilient (n = 23) = Stressed-resilient-Saline (n = 12) + Stressed-resilient-Indomethacin (n = 11); Stressed-susceptible (n = 20) = Stressed-susceptible-Saline (n = 10) + Stressed-susceptible-Indomethacin (n = 10). Values are expressed as means (±SEM).

&p<0.05

&&&p<0.001 vs Non-stressed group

###p<0.001 vs Stressed-resilient group

*p≤0.05

**p<0.01

***p<0.001 vs target absent.