Table 2. Cortical bone variables of stroke and control rats at ultra- distal and mid-shaft of femur.
| Stroke | Control | p-value# | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Left / Paretic | Right / Non-paretic | STS % Diff^ | Left | Right | STS % Diff^ | Left | Right | STS | |
| n = 11 | n = 10 | n = 10 | n = 8 | n = 8 | n = 8 | ||||
| Ultra-distal Femur | |||||||||
| TV | 5.7 (5.7, 6.0) | 5.6 (5.6, 5.8) | -2.2 (-3.5, 2.2) | 5.6 (5.5, 5.7) | 6.0 (5.6, 6.1) | 6.4 (1.2, 7.6) | 0.05 | 0.25 | 0.03 |
| BV | 5.1 (5.0, 5.2) | 4.9 (4.8, 5.0) | -2.0 (-8.4, 2.9) | 5.0 (4.8, 5.1) | 5.2 (5.0, 5.3) | 5.6 (3.2, 6.9) | 0.25 | 0.06 | 0.02 |
| vBMD | 853.2 (837.4, 869.0) | 819.5 (800.8, 830.6) | -5.1 (-7.1, 3.1) | 869.9 (836.4, 883.2) | 863.0 (848.3, 872.5) | -0.8 (-1.0, 0.5) | 0.42 | 0.02 | 0.16 |
| TMD | 967.6 (959.7, 975.2) | 951.8 (943.3, 958.1) | -1.8 (-2.8, -0.4) | 973.0 (960.4, 986.3) | 973.4 (969.2, 981.7) | 0.1 (-0.6, 1.1) | 0.89 | 0.33 | 0.53 |
| Mid-Shaft | |||||||||
| TV | 13.8 (13.4, 14.8) | 13.8 (13.4, 14.2) | 1.4 (-0.2, 3.0) | 14.0 (13.6, 14.2) | 14.0 (13.3, 14.0) | 2.3 (-0.5, 3.4) | 0.05 | 0.25 | 0.03 |
| BV | 11.3 (10.8, 11.9) | 11.5 (11.0, 11.6) | 0.7 (0.1, 1.6) | 11.6 (11.3, 11.7) | 11.6 (11.1, 11.7) | 1.5 (-0.1, 1.9) | 0.79 | 0.66 | 0.66 |
| vBMD | 1045.1 (1035.2, 1049.2) | 1053.1 (1050.2, 1059.5) | -1.1 (-4.8, 2.3) | 1043.0 (1038.1, 1058.4) | 1058.6 (1056.2, 1060.6) | -5.8 (-7.5, -0.1) | 0.59 | 0.29 | 0.33 |
| TMD | 1125.4 (1120.8, 1131.3) | 1128.8 (1123.6, 1132.6) | 1.3 (-1.7, 2.6) | 1126.3 (1120.8, 1132.0) | 1131.3 (1130.7, 1134.8) | 0.3 (-1.9, 1.4) | 0.89 | 0.33 | 0.53 |
| Ct. Ar | 6.63 (6.47, 6.95) | 6.64 (6.55, 6.73)§ | -0.78 (-3.31, 0.07) § | 6.81 (6.49, 6.83)¥ | 6.67 (6.37, 6.75) | -1.55 (-4.10, -0.72) ¥ | 0.82 | 0.92 | 0.43 |
| Ct. Th | 0.20 (0.18, 0.23) | 0.23 (0.21, 0.24)§ | 3.03 (-2.89, 14.43) § | 0.21 (0.19, 0.22) ¥ | 0.23 (0.22, 0.25) | 12.5 (-4.12, 25.79) ¥ | 0.82 | 0.67 | 0.88 |
Note. Median values (IQR) presented.
^ Side-to-side % difference; calculated [(right leg–left leg)/ left leg] x 100
#Between-group comparison: Wilcoxon rank-sum test
§ n = 9,
¥ n = 7: data missing due to software error
BV = Bone volume, mm3; BV/TV = Bone volume fraction, %; Conn. D = Connective density, 1/mm;), Ct. Th = cortical thickness, mm,; Ct. Ar = cortical area, mm2) TMD = Tissue mineral density, mg HA/cm3; SMI = Structural model index (0 = parallel plates, 3 = cylindrical rods); Tb. N = Trabecular number, 1/mm; Tb. Th = Trabecular thickness, μm; Tb Sp = Trabecular separation, mm; TV = Total volume, mm3; vBMD = volumetric bone mineral density, mg HA/cm3