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. 2017 Mar 9;12(3):e0172889. doi: 10.1371/journal.pone.0172889

Table 3. Bone turnover markers in rats: Percentage change from baseline.

Stroke Control p-value^
Median (IQR) Median (IQR)
CTX, %
Day 7 -7.1 (-19.1, 24.7) n = 8 1.3 (-27.1, 24.0) n = 8 0.46
Day 27 4.9 (-5.7, 30.5) n = 9 0.7 (-34.2, 27.4) n = 7 0.79
P1NP, %
Day 7 -44.1 (-58.8,-26.1) n = 6 -23.8 (-35.7,-14.5) n = 6 0.42
Day 27 -24.5 (-34.1,-10.5) n = 6^^ -0.8 (-3.4, 43.1) n = 5 0.41

CTX = Degradation products of C-terminal telopeptides of type 1 collagen, bone resorption marker. P1NP = N-terminal propeptide of type 1 procollagen, bone formation marker

^Wilcoxon rank-sum comparison between stroke and control animals

^^One-sample median test compared to baseline value, p = 0.046.