Table 1. Clinical features of papillary or follicular thyroid cancer with bone metastasis in different group.
| Clinical Characteristic | All patients | Group A vs. B | P value | |
|---|---|---|---|---|
| Group A | Group B | |||
| Patient number (%) | 131 (100.0) | 90 (68.7) | 41 (31.3) | |
| Gender, Female (%) | 94 (71.8) | 65 (72.2) | 29 (70.7) | 0.861 |
| Age at diagnosis (year) | 57.4 ± 15.0 | 59.1 ± 13.2 | 53.7 ± 18.0 | 0.058 |
| (range) | (11–87) | (11–87) | (11–87) | |
| Mean tumor size (cm) | 4.1 ± 2.9 | 3.8 ± 2.6 | 4.6 ± 3.3 | 0.151 |
| (range) | (0.5–18.0) | (0.5–11.1) | (0.7–18.0) | |
| Median post-operative serum Tg level after 1 month (ng/mL) | 300 | 520 | 29 | 0.008 |
| (range) | (0.0–141970.0) | (1.7–141970.0) | (0.0–7890.0) | |
| Multifocality | 15 (11.5) | 10 (11.1) | 5 (12.2) | 0.857 |
| Operative method | ||||
| Total thyroidectomy | 87 (66.4) | 56 (62.2) | 31 (75.6) | 0.132 |
| Less than total thyroidectomy | 44 (33.6) | 34 (37.8) | 10 (24.4) | |
| Histology | ||||
| Papillary | 79 (60.3) | 45 (50.0) | 34 (82.9) | <0.001 |
| Follicular | 52 (39.7) | 45 (50.0) | 7 (17.1) | |
| TNM stage | ||||
| Stage I | 10 (7.6) | - | 10 (24.4) | <0.001 |
| Stage II | 19 (14.5) | 12 (13.3) | 7 (17.1) | |
| Stage III | 8 (6.1) | - | 8 (19.5) | |
| Stage IV | 94 (71.8) | 78 (86.7) | 16 (39.0) | |
| Follow-up period (year) | 8.4 ± 7.0 | 6.6 ± 6.4 | 12.2 ± 6.8 | <0.001 |
| Post-operative 131I accumulative dose (mCi) | 451.4 ± 480.8 | 412.2 ± 470.3 | 537.4 ± 492.2 | 0.200 |
| (range) | (0.0–2787.1) | (0.0–2000.0) | (0.0–2787.1) | |
| Radiation therapy | 68 (51.9) | 51 (56.7) | 17 (41.5) | 0.106 |
| 131I avid lesion | 98 (74.8) | 65 (72.2) | 33 (80.5) | 0.312 |
| Brain metastasis | 8 (6.1) | 7 (7.8) | 1 (2.4) | 0.184 |
| Total mortality | 96 (73.3) | 73 (81.1) | 23 (56.1) | 0.237 |
| Cancer mortality | 88 (67.2) | 69 (76.7) | 19 (46.3) | 0.003 |
| Excellent response | 13 (9.9) | 5 (5.6) | 8 (19.5) | 0.001 |
Number (%)