Table 1.

Fabrication conditions of microspheres

Group	PLGA (mg)	Rifapentine (mg)	Linezolid (mg)	Stirring rate (rpm)	Drug-to-polymer ratio
1	600	–	–	1,000	–
2	600	100	100	1,000	1:3
3	600	150	150	1,000	1:2
4	600	250	250	1,000	5:6
5	600	250	250	800	5:6
6	600	250	250	1,400	5:6
7	600	150	350	1,000	5:6
8	600	200	300	1,000	5:6

Notes: n=3, drug-to-polymer ratio refers to the weight ratio of rifapentine and linezolid to PLGA; Group 1 comprises the drug-unloaded microspheres. Groups 1–8 represent different fabrication conditions of microspheres. Each group has different a mass ratio of rifapentine and linezolid, stirring rate. and drug-to-polymer ratio of miscrospheres.

Abbreviation: PLGA, poly(lactic acid-co-glycolic acid).