Table 2. Planktonic and biofilm bacteria sensitivity to FLIP7 and reference antibiotics (TTC assay).
Strain | Planktonic bacteria MIC, μg/mL | Biofilm bacteria MBIC90, μg/mL | P* | MBIC90/ MIC ratio |
---|---|---|---|---|
E. coli ATCC 25922 | ||||
FLIP7 | 500 ± 0.00 | 1667 ± 88 | <0.001 | 3.3 |
Cefotaxime | 0.125 ± 0.00 | 3 ± 0.7 | 0.005 | 24 |
Meropenem | 0.03 ± 0.00 | 0.9 ± 0.3 | <0.001 | 30 |
Polymyxin | 0.5 ± 0.00 | 12.3 ± 0.3 | <0.001 | 24.6 |
E. coli NCTC 13353 | ||||
FLIP7 | 250 ± 0.00 | 2567 ± 617 | 0.02 | 10.3 |
Meropenem | 0.06 ± 0.00 | 2.3 ± 0.9 | 0.073 | 38.3 |
Polymyxin | 1.3 ± 0.3 | 52 ± 14 | 0.022 | 40.0 |
S. aureus 203 | ||||
FLIP7 | 667 ± 167 | 1543 ± 137 | 0.015 | 2.3 |
Meropenem | 0.03 ± 0.005 | >5 | >167 | |
Vancomycin | 0.5 ± 0.00 | 25± 13 | 0.134 | 50 |
S. aureus 73.1 | ||||
FLIP7 | 8000 ± 0.00 | 7333 ± 167 | 0.016 | 0.9 |
Meropenem | 0.08 ± 0.00 | 0.29 ± 0.08 | 0.06 | 3.6 |
A. baumannii 28 | ||||
FLIP7 | 125 ± 0.00 | 6433 ± 1417 | 0.011 | 51 |
Polymyxin B | 0.4 ± 0.1 | 267 ± 67 | 0.016 | 667 |
A. baumannii 143 | ||||
FLIP7 | 125 ± 0.00 | 3767 ± 33 | <0.001 | 30 |
Polymyxin B | 0.25 ± 0.00 | >20 | >80 | |
A. baumannii 149.2 | ||||
FLIP7 | 416 ± 83 | 7600 ± 306 | <0.001 | 18 |
Meropenem | 0.5 ± 0.00 | 1.5 ± 0.06 | <0.001 | 3 |
Polymyxin B | 0.7 ± 0.2 | 30.3 ±6.2 | 0.009 | 43 |
*Each test consisted of 3 independent measurements