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. 2017 Jan 13;10(1):66. doi: 10.3390/ma10010066

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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SEM images of the micro-fabrication before the optimization. Instability and deformation on (a) three elementary nichoids; (b) on the substrate composed of 367 elementary nichoids; (c) Collapse of the culture substrate covered with continuously-packed nichoids (CPN), more likely due to cavitation phenomena and vibration during the manufacturing process; (d) Instability issues in the culture substrate covered with a fractionated supermatrix of nichoids (FSN), including 218 matrixes at a distance of 30 µm.

SEM images of the micro-fabrication before the optimization. Instability and deformation on (a) three elementary nichoids; (b) on the substrate composed of 367 elementary nichoids; (c) Collapse of the culture substrate covered with continuously-packed nichoids (CPN), more likely due to cavitation phenomena and vibration during the manufacturing process; (d) Instability issues in the culture substrate covered with a fractionated supermatrix of nichoids (FSN), including 218 matrixes at a distance of 30 µm.