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. 2017 Mar 6;27(5):624–637. doi: 10.1016/j.cub.2017.01.033

Figure 1.

Figure 1

Loss of Cdc42 in the Melanoblast Lineage Leads to Coat Color Defects in Adult Mice

(A) Schematic of the gene-targeting strategy for Cdc42 f/f; Tyr::CreB+ mice.

(B) Coat color of control Cdc42 wt/wt (Ctr) mice and Cdc42 f/f; Tyr::CreB+ mice at P22. Yellow arrows indicate dorsal white patches.

(C) Sections from dorsal and ventral Ctr and Cdc42 f/f; Tyr::CreB+ pup skin stained with anti-DCT (melanocyte, red) and hematoxylin counterstain (blue). Scale bars, 100 μm. The far-right panels show hair follicles. N = 20 mice.

See also Figure S1.