Extended Data Fig. 1. Characterization of autophagy-deficient Atg12cKO mice.
a, CBC analyses of lymphocytes and hematocrit in control (Cnt) and Atg12cKO (cKO) mice post-pIC treatment. b, Lineage distribution in PB of Ctrl and cKO mice at 2 months post-pIC, and in young and old mice; My: myeloid; Ly: lymphoid. c, Total cell numbers in PB, spleen (Spl), and BM of Ctrl and cKO mice at 2 months post-pIC. d, Gating strategy for mature populations; ImGr: imature granulocytes/monocytes; Gr: granulocyte; B: B cells. e, f, Mature populations in (e) BM and (f) spleen of Ctrl and cKO mice at 2 months post-pIC. g, Gating strategy for imature BM populations; Lin: lineage negative; MP: myeloid progenitors; CMP: common myeloid progenitor; MEP: megakaryocyte/erythrocyte progenitor. h, Quantification of immature BM populations in Ctrl and cKO mice at 2 months post-pIC; CLP: common lymphoid progenitor. i, HSC frequency over time in Ctrl and cKO mice post-pIC. j, Quantification of MP BM populations in Ctrl and cKO mice at 2 months post-pIC. k, Colony formation in methylcellulose from Cnt and cKO BM at 2 months post-pIC. Data are mean ± S.D.*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.