Image analysis methods and outputs
Lesions
Type (e.g. Gd-enhancing, T2-hyperintense, T1-hypointense)	GSH quantification
Analysis method	Internal reference method using simultaneously acquired creatine signals
Analysis software	In-house software written in IDL
Output measure (e.g. count or volume [ml])	µmol/g tissue
Tissue volumes
Type (e.g. whole brain, grey matter, white matter, spinal cord)
Analysis method
Analysis software
Output measure (e.g. absolute tissue volume in ml, tissue volume as a fraction of intracranial volume, percentage change in tissue volumes)
Tissue measures (e.g. MTR, DTI, T1-RT, T2-RT, T2*, T2’, 1H-MRS, perfusion, Na)
Type (e.g. whole brain, grey matter, white matter, spinal cord, normal-appearing grey matter or white matter)
Analysis method
Analysis software
Output measure
Other MRI measures (e.g. functional MRI)
Type (e.g. whole brain, grey matter, white matter, spinal cord, normal-appearing grey matter or white matter)
Analysis method
Analysis software
Output measure