Image analysis methods and outputs
Lesions
Type (e.g. Gd-enhancing, T2-hyperintense, T1-hypointense)	Creatine quantification
Analysis method	LCModel analysis with an external reference method and partial tissue volume fraction correction
Analysis software	LCModel and in-house software written in Matlab
Output measure (e.g. count or volume [ml])	µmol/g tissue in an institutional unit
Tissue volumes
Type (e.g. whole brain, grey matter, white matter, spinal cord)
Analysis method
Analysis software
Output measure (e.g. absolute tissue volume in ml, tissue volume as a fraction of intracranial volume, percentage change in tissue volumes)
Tissue measures (e.g. MTR, DTI, T1-RT, T2-RT, T2*, T2’, 1H-MRS, perfusion, Na)
Type (e.g. whole brain, grey matter, white matter, spinal cord, normal-appearing grey matter or white matter)
Analysis method
Analysis software
Output measure
Other MRI measures (e.g. functional MRI)
Type (e.g. whole brain, grey matter, white matter, spinal cord, normal-appearing grey matter or white matter)
Analysis method
Analysis software
Output measure