Table 5.

BOLD signal and CI.

Subjects by order of enrollment	1-10 (1 excluded) MSNI (n9)	11-30 (5 excluded) MSCI (n15)	31-50 (5 excluded) MSCI (n15)
T2 Lesion volume mean and SD	6.007 (6.520)	29.085 (20.591)	20.833 (18.668)
T2 Lesion volume (ml) median	3.063	17.877	18.744
Disease duration (y) mean and SD	9.65 (8.192)	16.6 (11.356)	13.533 (7.501)
Disease duration median	7	13	12
EDSS mean and SD	1.3 (0.788)	4.066 (1.591)	4.433 (2.042)
EDSS median	1	3	6
ii mean	0.075 (0.054)	0.64 (0.1638)	0.54 (0.1466)
ii median	.05	0.6	0.5

Preliminary analysis between 10 MSNI vs. the first 15 MSCI patients (by order of enrollment), showed significantly greater BOLD signal in MSCI during DI5 (unlike final analysis), this was explained by differences between the MSCI groups; the first group of 15 patients enrolled had higher LV, DD and ii than the second group of 15 enrolled (4 MSBD and 6 MSCI excluded). This supports that I/DMT may detect various degrees of CI.