Table 1. Baseline results of selected European low-dose computed tomography lung cancer screening trials.
| Variables | UKLS (21) | DANTE (4,22) | DLCST (4,23) | NELSON (4,24,25) | ITALUNG (4,26) | LUSI (4,27) |
|---|---|---|---|---|---|---|
| Participants | ||||||
| Received CT screening | 1,994 | 1,276 | 2,052 | 7,557 | 1,406 | 2,029 |
| Age, mean [SD] | 67 [4] | 65 [5] | 57 [5] | 59 [6] | 61 [4] | 58 [5] |
| Pack years, mean [SD] | NA | 47 [25] | 36 [13] | 42 [19] | 43 [18] | 36 [18] |
| Nodule detection limit | ≥15 mm3/≥3 mm | None reported | None reported | ≥15 mm3 | ≥5 mm | ≥5 mm |
| Participants with lung cancer | 42/1,994 (2.1%) | 28/1,276 (2.2%) | 17/2,052 (0.8%) | 70/7,557 (0.9%) | 20/1,406 (1.4%) | 22/2,029 (1.1%) |
| Participants with NCNs | 1,015/1,994 (50.9%) | NA | 447/2,052 (21.8%) | 3,816/7,557 (50.5%) | 426/1,406 (30.3%) | 540/2,029 (26.6%) |
| % with lung cancer | 42/1,015 (4.1%) | NA | 17/447 (3.8%) | 70/3,816 (1.8%) | 20/426 (4.7%) | 22/540 (4.1%) |
| % of NCNs being lung cancer | NA | NA | 17/560 (3.0%) | 74/8,623 (0.9%) | 21/639 (3.3%) | NA |
| Lung cancer | ||||||
| Stage I | 28/42 (66.7%) | 16/28 (57.1%) | 9/17 (53.0%) | 48/74 (64.9%) | 10/21 (47.6%) | 18/22 (81.8%) |
| Histology | ||||||
| Adenocarcinoma† | 25/42 (59.5%) | 17/28 (60.7%) | 12/17 (70.6%) | 37/74 (50.0%) | 10/21 (47.6%) | 15/22 (68.2%) |
| Squamous-cell carcinoma | 12/42 (28.6%) | 8/28 (28.6%) | 2/17 (11.8%) | 15/74 (20.3%) | 6/20 (30.0%) | 3/22 (13.6%) |
| Small-cell Lung cancer | 3/42 (7.1%) | 2/28 (7.1%) | 0 | 1/74 (1.4%) | 1/21 (4.7%) | 1/22 (4.5%) |
| Others | 2/42 (4.8%) | 1/28 (3.6%) | 3/17 (17.6%) | 21/74 (28.4%) | 4/21 (19.0%) | 3/22 (13.6%) |
†, bronchioloalveolar carcinomas are considered adenocarcinomas. UKLS, United Kingdom lung screening trial; DANTE, detection and screening of early lung cancer by novel imaging technology and molecular assays; DLCST, Danish lung cancer screening trial; NELSON, Dutch-Belgian lung cancer screening trial; ITALUNG, Italian lung study; LUSI, German lung cancer screening intervention study; SD, standard deviation; NCNs, non-calcified pulmonary nodules; NA, not available.