Table 2. Subgroup-analysis of the association between β-catenin expression in different subcellular location and survival.

Subgroup	No. of studies	HR (95% CI)	Heterogeneity
			I2 (%)	P
Membrane (18,28,30,34,36-38)
Overall effect	7	0.53 (0.32–0.87)	78.6	0.000
Analysis model
Univariate	3	0.38 (0.24–0.60)	0.0	0.863
Multivariate	4	0.64 (0.33–1.21)	84.0	0.000
HR estimate
Reported in text	4	0.59 (0.33–1.04)	81.7	0.000
By estimate	2	0.36 (0.32–0.64)	0.0	0.653
Patients’ number
<100	4	0.41 (0.30–0.57)	0.0	0.907
≥100	3	0.72 (0.34–1.53)	81.3	0.005
Study location
Asia	6	0.57 (0.34–0.97)	78.7	0.000
Non-Asia	1	0.31 (0.14–0.68)
Cytoplasm (18,25-27,33)
Overall effect	10	1.64 (1.34–1.99)	36.5	0.116
Analysis model
Univariate	4	1.35 (1.00–1.86)	36.6	0.192
Multivariate	6	1.85 (1.43–2.38)	31.1	0.202
HR estimate
Reported in text	9	1.64 (1.33–2.01)	43.6	0.077
By estimate	1	1.62 (0.83–3.17)
Patients’ number
<100	4	1.75 (0.98–3.12)	0.0	0.412
≥100	6	1.62 (1.32–2.00)	55.6	0.047
Study location
Asia	8	1.60 (1.30–1.97)	40.5	0.108
Non-Asia	2	2.05 (1.05–3.99)	48.2	0.165
Abnormal expression (17,29,31,32,35)
Overall effect	5	1.38 (0.61–3.15)
Patients’ number
<100	1	6.29 (0.71–55.56)
≥100	4	1.18 (0.50–2.77)	80.1	0.002

CI, confidence interval; HR, hazard ratio.