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. 2017 Feb 9;79(3):507–518. doi: 10.1007/s00280-017-3240-x

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Mean plasma concentration–time profiles of TRA, ponatinib, and metabolites M14 (AP24600), M23 (AP32318), and M42 (AP24567). Error bars represent SD; n = 6. TRA in plasma was determined using liquid scintillation counting. Ponatinib and its metabolites (M14 and M42) were quantitated using LC/MS/MS methods, whereas M23 was quantitated by radiochromatography [M23 (nM) = ponatinib concentration (nM) × radioactivity ratio of M23/ponatinib]. LC/MS/MS liquid chromatography with tandem mass spectrometry. SD standard deviation, TRA total radioactivity