Table 1. Demographic and symptom data.
| Control (N = 33) | Major depression (N = 65) | |
|---|---|---|
| Male/female participants | 14/19 | 17/48 |
| Age (years) | 33.00 ± 11.31 | 37.92 ± 11.48 |
| Verbal intelligence quotienta | 105.15 ± 14.90 | 107.06 ± 12.18 |
| BDI-II | ||
| Time 1 | 1.55 ± 2.05 (33) | 30.71 ± 7.75 (65) |
| Time 2 | 1.40 ± 2.19 (30) | 22.83 ± 10.70 (53) |
| Time 3 | 1.28 ± 1.79 (29) | 19.12 ± 12.79 (49) |
| Time 4 | 1.64 ± 2.57 (33) | 17.14 ± 13.34 (64) |
| BDI-II Anhedonia subscaleb | ||
| Time 1 | 0.39 ± 0.83 (33) | 6.32 ± 2.23 (65) |
| Time 2 | 0.42 ± 1.03 (31) | 4.74 ± 2.72 (53) |
| Time 3 | 0.24 ± 0.64 (29) | 3.79 ± 2.97 (52) |
| Time 4 | 0.39 ± 0.86 (33) | 3.45 ± 2.84 (65) |
| State Anxiety Scale | ||
| Time 1 | 28.48 ± 6.55 (33) | 49.05 ± 10.82 (65) |
| Time 2 | 27.39 ± 6.35 (31) | 46.47 ± 10.97 (53) |
| Time 3 | 27.86 ± 7.72 (29) | 42.04 ± 12.40 (51) |
| Time 4 | 27.79 ± 6.73 (33) | 39.52 ± 12.76 (64) |
| MASQ subscales | ||
| Anhedonic Depression | ||
| Time 1 | 45.09 ± 8.97 (33) | 83.11 ± 9.12 (65) |
| Time 2 | 43.29 ± 9.84 (31) | 71.63 ± 14.39 (52) |
| Time 3 | 42.86 ± 10.72 (29) | 66.47 ± 18.96 (51) |
| Time 4 | 43.38 ± 10.36 (32) | 65.00 ± 16.86 (65) |
| Anxious Arousal | ||
| Time 1 | 18.55 ± 1.99 (33) | 26.85 ± 7.25 (65) |
| Time 2 | 18.39 ± 1.87 (31) | 23.79 ± 6.90 (52) |
| Time 3 | 18.69 ± 3.29 (29) | 23.80 ± 8.31 (51) |
| Time 4 | 18.28 ± 1.49 (32) | 23.62 ± 8.21 (65) |
| GD: Anxiety | ||
| Time 1 | 14.48 ± 2.59 (33) | 25.03 ± 6.97 (65) |
| Time 2 | 13.42 ± 2.47 (31) | 20.81 ± 6.18 (52) |
| Time 3 | 14.00 ± 2.60 (29) | 20.59 ± 7.57 (51) |
| Time 4 | 13.44 ± 2.06 (32) | 18.95 ± 6.86 (65) |
| GD: Depression | ||
| Time 1 | 15.72 ± 2.82 (33) | 38.94 ± 8.91 (65) |
| Time 2 | 15.16 ± 2.27 (31) | 31.10 ± 9.57 (52) |
| Time 3 | 15.07 ± 3.62 (29) | 27.49 ± 11.08 (51) |
| Time 4 | 15.09 ± 2.44 (32) | 26.68 ± 11.74 (65) |
| GD: Mixed | ||
| Time 1 | 22.55 ± 4.49 (33) | 45.91 ± 8.41 (65) |
| Time 2 | 21.03 ± 4.53 (31) | 39.08 ± 9.13 (52) |
| Time 3 | 20.79 ± 3.80 (29) | 37.00 ± 11.01 (51) |
| Time 4 | 21.38 ± 4.83 (32) | 34.55 ± 11.16 (65) |
BDI-II, Beck Depression Inventory, Second Edition; State Anxiety Scale, State Anxiety Scale of the State-Trait Anxiety Inventory; MASQ, Mood and Anxiety Symptom Questionnaire; GD, General Distress; aVerbal intelligence quotient scores were measured with the Wechsler Test of Adult Reading (WTAR); bThe Anhedonia subscale was created by summing responses on the following BDI-II items associated with anhedonia symptoms: loss of pleasure (item 4), loss of interest (item 12), loss of energy (item 15), and loss of interest in sex (item 21). Numbers of participants who were included for calculating mean and standard deviation of each questionnaire score are noted in parentheses; see Supplementary Fig. S1 for the BDI-II, State Anxiety Scale, and MASQ scores in the smallest subset of included participants (visiting all four times), and see Methods for details about inclusion criteria.