Table 3. Effect of estrogen and vildagliptin on cardiac function at the end of myocardial ischemia.
| Parameters | NDS | NDO |
HFO |
||||
|---|---|---|---|---|---|---|---|
| Ve | E | Vil | Ve | E | Vil | ||
| Heart rate (bpm) | 218 ± 18 | 241 ± 20 | 205 ± 26 | 221 ± 29 | 236 ± 11 | 221 ± 12 | 224 ± 21 |
| LVESP (mmHg) | 92 ± 5 | 61 ± 9* | 87 ± 4† | 79 ± 2† | 46 ± 5 | 95 ± 5‡ | 85 ± 17‡ |
| LVEDP (mmHg) | 17 ± 2 | 27 ± 4 | 20 ± 5 | 17 ± 5 | 30 ± 2 | 16 ± 1‡ | 16 ± 2‡ |
| +dP/dt (mmHg/sec) | 5478 ± 642 | 4154 ± 1472 | 5521 ± 1032 | 5258 ± 264 | 3974 ± 1062 | 5712 ± 1174 | 5544 ± 937 |
| −dP/dt (mmHg/sec) | −4638 ± 1483 | −1521 ± 522* | −3547 ± 563 | −3126 ± 111 | −1745 ± 635 | −3802 ± 962 | −3926 ± 850 |
| SV/BW (μl/gram) | 0.90 ± 0.05 | 0.48 ± 0.04* | 1.04 ± 0.05† | 0.85 ± 0.05† | 0.30 ± 0.05† | 0.53 ± 0.06‡ | 0.51 ± 0.09‡ |
Values are mean ± SEM (n = 6 per group). *P < 0.05 vs NDS, †P < 0.05 vs NDOVe, and ‡P < 0.05 vs HFOVe. NDS, normal-diet fed sham-operated rats; NDO, normal-diet fed ovariectomized rats; HFO, high-fat-diet fed ovariectomized rats; Ve, vehicle; E, estradiol; Vil, vildagliptin; LVESP, left ventricular end systolic pressure; LVEDP, left ventricular end diastolic pressure; +dP/dt, maximal slope of the systolic pressure increment; −dP/dt, maximal slope of the diastolic pressure decrement; SV/BW, stroke volume/body weight.