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. 2017 Mar 10;7:44492. doi: 10.1038/srep44492

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Copyright © 2017, The Author(s)

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(A) Representative images of glomeruli (PAS-stained sections) from wt/ob, ob/ob and ob/ob carnosine-supplemented mice. (B,C and D) Surface areas of Bowman’s capsule (B), Bowman’s space (C) and the glomerular tuft (D) were increased in ob/ob mice, while carnosine treated mice showed a reduction in the area of Bowman’s capsule and space. (E) Surface area of Bowman’s space positively correlated with glycemia, HbA1c and albumin-creatinine ratio (ACR). Data represents means ± SEM. *P < 0.05 compared to ob/ob mice. ^####P < 0.0001 compared to wt/ob mice. Car: carnosine.