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. 2017 Mar 10;7:44492. doi: 10.1038/srep44492

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Copyright © 2017, The Author(s)

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(A) Representative images of glomeruli immunostained for fibronectin (brown) and counterstained with hematoxylin in wt/ob, ob/ob and ob/ob carnosine-supplemented mice. (B) The quantity of fibronectin protein was increased in ob/ob mice compared to wt/ob controls. A trend was observed towards lower fibronectin content in carnosine-treated animals. (C) Fibronectin mRNA expression (shown relative to the wt/ob group) was significantly decreased in carnosine-treated mice compared to ob/ob controls. (D) The quantity of fibronectin protein positively correlated with glycemia, HbA1c and albumin-creatinine ratio (ACR). Data represents means ± SEM. *P < 0.05, ^οP = 0.09, ^θP = 0.058 compared to ob/ob mice. ^##P < 0.01 compared to wt/ob mice. Car: carnosine.