Table 4.

Adjusted associations between antibiotic orders and other allergies at different age of diagnosis up to 7 years of age

			Allergy diagnosed up to 1000 days of age (2.74 years)			Allergy diagnosed after 1000 days of age (2.74 years)			All allergy diagnosed at any age up to 7 years
	Period of antibiotic assessment	Antibiotic order count	Odds ratio	95% confidence interval		Odds ratio	95% Confidence interval		Odds ratio	95% Confidence interval
Allergy cases with or without a diagnosis of a food allergy.†	Model 1: 0–12 months of age	1–2 vs. none	1.67	1.48	1.89	1.11	0.99	1.24	1.35	1.24	1.46
		3+ vs. none	2.49	2.17	2.85	1.27	1.11	1.45	1.75	1.59	1.92
	Model 2: 0–24 months of age	1–2 vs. none	1.85	1.60	2.14	1.10	0.95	1.28	1.46	1.31	1.62
		3+ vs. none	3.35	2.89	3.88	1.51	1.31	1.72	2.22	2.01	2.46
	Model 3: Until 60 days prior to diagnosis	1–2 vs. none	1.90	1.64	2.19	1.22	0.97	1.54	1.69	1.50	1.92
		3+ vs. none	3.54	3.04	4.11	2.23	1.82	2.73	3.07	2.72	3.46
Allergy cases excluding cases with a diagnosis of a food allergy.‡	Model 1: 0–12 months of age	1–2 vs. none	1.68	1.48	1.92	1.08	0.95	1.21	1.32	1.21	1.44
		3+ vs. none	2.54	2.19	2.94	1.29	1.13	1.48	1.76	1.60	1.95
	Model 2: 0–24 months of age	1–2 vs. none	1.91	1.64	2.23	1.09	0.93	1.27	1.46	1.61	1.63
		3+ vs. none	3.50	2.98	4.10	1.49	1.29	1.71	2.22	2.00	2.47
	Model 3: Until 60 days prior to diagnosis	1–2 vs. none	1.96	1.67	2.29	1.19	0.94	1.50	1.71	1.50	2.00
		3+ vs. none	3.72	3.16	4.37	2.17	1.76	2.67	3.12	2.74	3.54

^*Adjusted for Medical Assistance and race/ethnicity

^†Includes allergy cases with and without diagnoses of food allergies: < 1001 days includes 1817 cases vs. 9085 controls; >1000 days includes 1835 cases vs. 9175 controls; diagnosed up to 7 years includes 3652 cases vs. 18260 controls.

^‡Excludes cases with a diagnosis of a food allergy: < 1001 days includes 1594 cases vs. 7970 controls; >1000 days includes 1704 cases vs. 8520 controls; diagnosed up to 7 years includes 3298 cases vs. 16490 controls.