Table 2.
Infection and treatment characteristics and association with primary cure
| Variable | Baseline | Primary success rate | P value | |
|---|---|---|---|---|
| (n = 49) | No (n = 18) | Yes (n = 31) | ||
| Infection | ||||
| Type of infection | 0.260 | |||
| Early | 44 | 15 | 29 | |
| Delayed | 5 | 3 | 2 | |
| Microorganism | ||||
| Negative culture | 5 | 1 | 4 | 0.623 |
| Staphylococcus aureus | 16 | 6 | 10 | 1.0 |
| CoNS | 2 | 1 | 1 | 1.0 |
| Polymicrobial culture | 21 | 10 | 11 | 0.206 |
| Other single microorganism | 4 | – | 4 | 0.282 |
| Rifampicin resistance at first culture | 3 | 2 | 1 | 0.544 |
| Rifampicin resistance in all cultures | 8 | 5 | 3 | 0.250 |
| Treatment | ||||
| Number of debridements performed | 2 (0–14) | 3 (0–14) | 2 (1–5) | 0.015 |
| Closure | ||||
| Primary closure | 23 | 4 | 19 | 0.017 |
| VAC therapy after debridement | 17 | 10 | 7 | 0.030 |
| Time to closure after debridement, days | 157 (8–700) | 271 (38–700) | 149 (8–157) | 0.000 |
| Antibiotic therapy | ||||
| Duration i.v. antibiotic therapy | 10 (0–116) | 14 (0–77) | 10 (0–116) | 0.203 |
| Duration oral antibiotic therapy | 70 (0–112) | 63 (0–89) | 70 (0–112) | 0.033 |
| Duration total antibiotic therapy | 80 (0–126) | 80 (0–126) | 81 (9–116) | 0.186 |
| Duration of rifampicin therapy | 80 (5–116) | 75 (6–97) | 80 (5–116) | 0.118 |
| NSAID use during treatment | 36 | 14 | 31 | 0.743 |
| Treated according to protocol | 0.025 | |||
| Yes | 39 | 11 | 28 | |
| No | 10 | 7 | 3 | |
Data are presented as the number of cases with the percentage in parenthesis or as median with the range in parenthesis
i.v. intravenous
P values of <0.05 are considered significant. Only P values of <0.05 are in italic