Table 2.
Characteristics of the 22 patients harbouring carbapenem-resistant K. pneumoniae
| N° | % | |
|---|---|---|
| PATIENTS | 22 | |
| Male gender | 13 | 59 |
| Age (years), mean (range) | 53.7 (28–76) | |
| N° of patients who developed CRKP bacteremia | 14 | 64 |
| - Previously identified as CRKP rectal carriers | 11 | |
| N° of patients who remained CRKP rectal carriers | 8 | 36 |
| UNDERLYING HAEMATOLOGIC MALIGNANCY | ||
| Acute leukemia | 16 | 73 |
| - Acute myeloid leukemia | 12 | 55 |
| Other haematologic malignancy | 6 | 27 |
| CHEMOTHERAPEUTIC TREATMENT | 20 | 91 |
| Intensive remission induction/reinduction | 8 | 40 |
| Intensive remission consolidation | 4 | 20 |
| Other chemotherapy | 8 | 40 |
| CHARACTERISTICS OF PATIENTS AT CRKP ACQUISITION (n° of patients) | ||
| Rectum as first site of CRKP isolation | 19 | 86 |
| Blood as first site of CRKP isolation | 3 | 14 |
| Ongoing fluoroquinolones oral prophylaxis | 11 | 50 |
| Ongoing systemic antibacterial treatment (carbapenem) | 9 (1) | 41 |
| Carbapenems within the last 4 weeks | 5 | 23 |
| <1000 neutrophils/mm3 | 12 | 55 |
| <100 neutrophils /mm3 | 10 | 45 |
| days with < 1000 neutrophils/mm3 before CRKP acquisition: mean, median (range), | 19.2,13 (2–53) | |
| days with < 100 neutrophils /mm3 before CRKP acquisition: mean, median (range) | 10.2, 4.5, (1-53) | |
| N° of patients negative at CRKP rectal screening performed at entry: | 19 | 86 |
| First hospitalization (n° of patients) | 14 | 64 |
| Transferred from other Departments | 2 | |
| Prior hospitalization (n° of patients) | 5 | 23 |
| During the period preceding CRKP acquisition: | ||
| Mean, median (range) days of previous hospitalization | 28, 17 (7–60) | |
| n°of patients hospitalized together with other CRKP-positive patients | 17/19 | |
| n°of patients hospitalized together with 4 or more CRKP carriers | 11/19 | 86 |
| n°of patients hospitalized together with 9 or more CRKP carriers | 6/19 | 64 |
| n°of patients hospitalized when clinical emergencies occurred in other CRKP-positive patients a | 14/19 | |
| CRKP bacteremia occurrence | 14/19 | |
| death for any cause in at least 1 CRKP-positive patients | 10/19 | |
| n° of patients temporary transferred to other Departments for invasive procedures | 4/19 | |
| N° of patients positive at CRKP rectal screening performed at entry | 3 | 14 |
| Previous hospitalization | 3 | |
| Transferred from other Departments (n° of patients) | 2 | |
| In the same Unit | 1 |
a5 patients had the first CRKP-positive rectal sample collected the same day in which a CRKP bacteremia and/or the death of a CRKP-positive patient occurred in the ward were they were hospitalized