Table 3.
Risk factors for bacteremia in the 19 patients colonized with carbapenem-resistant K. pneumoniae (CRKP) at univariate analysis
| Bacteremia | No bacteremia | p | |
|---|---|---|---|
| N° of CRKP colonized patients | 11 | 8 | |
| Male | 5 (45%) | 8 (100%) | |
| Female | 6 (54%) | 0 | 0.01 |
| Underlying disease | |||
| Acute leukemia | 10 (91%) | 3 (37.5%) | 0.0075 |
| Acute myeloid leukemia | 9 (82%) | 0 | 0.0007 |
| Other haematological malignancy | 1 (9%) | 5 (62.5%) | ns |
| Chemotherapy | 7 (64%) | 5 (62.5%) | ns |
| - Intensive induction chemotherapy | 6 (54%) | 0 | 0.01 |
| n° of patients with <1000 neutrophils/mm3 at CRKP acquisition | 5 (45%) | 4 (50%) | ns |
| n° of patients with <100 neutrophils/mm3 at CRKP acquisition | 4 (36%) | 3 (37%) | ns |
| Days spent colonized by CRKP with: | |||
| < 1000 neutrophils/mm3, mean, median (range) | 14.8, 10 (0–78) | 10.7, 5.5 (0–30) | <0.01 |
| < 100 neutrophils/mm3, mean, median (range) | 9.1, 8 (0–30) | 5.6, 3 (0–15) | <0.01 |
| Rectal colonization | 11 (100%) | 8 (100%) | ns |
| Single site colonization | 4 (36%) | 5 (62.5%) | ns |
| Multiple sites colonization | 7 (64%) | 3 (37%) | ns |
| Colonized sites besides the rectum | |||
| vagina/urethra | 3 | 0 | |
| urinary tract | 5 | 2 | |
| oral cavity, pharynx | 2 | 2 | |
| Mucositis | 6 (54%) | 3 (37%) | ns |
| - Diarrea | 6 | 3 | |
| CRKP localized infection | 7 (64%) | 3 (37.5%) | ns |
| vaginitis | 3 | 0 | ns |
| typhlitis | 2 | 1 | |
| hemorroidal cellulitis | 2 | 1 | |
| cellulitis | 0 | 1 | |
| Previous febrile neutropenia during CRKP colonization | 6 | 3 | ns |
| Previous bacteremia other than CRKP bacteremia during CRKP colonization | 4 | 2 | ns |
| Previous broad-spectrum antibiotics during CRKP colonization | 5 | 4 | ns |